TNFSF13B Gene Summary [Human]
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Details
| Type | Processed Transcript |
| Official Symbol | TNFSF13B |
| Official Name | TNF superfamily member 13b [Source:HGNC Symbol;Acc:HGNC:11929] |
| Ensembl ID | ENSG00000102524 |
| Bio databases IDs | |
| Aliases | TNF superfamily member 13b, B-cell-activating factor, TNF and ApoL-related leukocyte expressed ligand 1, TNF homolog that activates apoptosis, B-lymphocyte stimulator |
| Synonyms | BAFF, BLYS, CD257, D8Ertd387e, delta BAFF, DTL, RGD1561519, TALL-1, THANK, Tnfsf13c, TNFSF20, TNF superfamily member 13b, TNLG7A, tumor necrosis factor (ligand) superfamily, member 13b, tumour necrosis factor (ligand) superfamily, member 13b, ZTNF4, δ BAFF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFSF13B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- TNF homology domain
- TNF
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the TNFSF13B gene in human plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- B Cell Activating Factor Signaling
- Communication between Innate and Adaptive Immune Cells
- Erythropoietin Signaling
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- NF-κB Signaling
- RAR Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- kidney disease
- osteoarthritis
- glioma
- neoplasia
- COVID-19
- systemic lupus erythematosus
- idiopathic inflammatory myopathy
- periodontitis
- systemic sclerosis associated interstitial lung disease
- myositis
role in cell
- expression in
- activation in
- phosphorylation in
- binding in
- differentiation
- production in
- apoptosis
- number
- survival
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- cell borders
- perinuclear region
- membrane surface
- cellular membrane
- focal adhesions
- Plasma Membrane
- endosomes
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFSF13B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell costimulation
- signal transduction
- B cell costimulation
- B cell proliferation
- positive regulation of T cell proliferation
- skin development
- B cell homeostasis
- transitional one stage B cell differentiation
- germinal center formation
- tumor necrosis factor-mediated signaling pathway
- positive regulation of germinal center formation
- T cell proliferation
- positive regulation of B cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor receptor binding
- receptor agonist activity
- cytokine activity
- receptor binding