TCERG1 Gene Summary [Human]
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | TCERG1 |
| Official Name | transcription elongation regulator 1 [Source:HGNC Symbol;Acc:HGNC:15630] |
| Ensembl ID | ENSG00000113649 |
| Bio databases IDs | |
| Aliases | transcription elongation regulator 1, transcription factor CA150, co-activator of 150 kDa, TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD, TATA box-binding protein-associated factor 2S |
| Synonyms | 2410022J09Rik, 2900090C16Rik, CA150, CA150b, FBP23, FBP28, p144, TAF2S, transcription elongation regulator 1, transcription elongation regulator 1 (CA150), Urn1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TCERG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- Contains two conserved F residues
- transcription co-repressor
- nuclear localization sequence
- enzyme binding
- transcription factor binding
- protein binding
- identical protein binding
- polyproline motif
- WW domain
- transcriptional elongation regulator
- FF domain
- glutamine-alanine rich domain
- Domain with 2 conserved Trp (W) residues
- polyglutamine-alanine repeat
- STP box
- WW
- transcription factor activity
Pathways
Biological processes and signaling networks where the TCERG1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- Huntington disease
role in cell
- apoptosis
- cell death
- quantity
- processing in
- alternative splicing in
- mitosis
- splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- spliceosomes
- interchromatin space
- nucleoplasm
- nuclear speckles
- nuclear matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TCERG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA splicing
- negative regulation of transcription elongation from RNA polymerase II promoter
- mRNA processing
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- small protein conjugating enzyme binding
- transcription elongation regulator activity
- identical protein binding
- transcription cofactor activity
- RNA binding
- protein binding
- transcription coactivator activity
- transcription corepressor activity