CDK9 Gene Summary [Human]
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDK9 |
| Official Name | cyclin dependent kinase 9 [Source:HGNC Symbol;Acc:HGNC:1780] |
| Ensembl ID | ENSG00000136807 |
| Bio databases IDs | |
| Aliases | cyclin dependent kinase 9 |
| Synonyms | C-2k, CDC2L4, CTK1, cyclin-dependent kinase 9, PITALRE, TAK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDK9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase
- [RNA-polymerase]-subunit kinase
- snRNA binding
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- nucleic acid binding
- transcription factor binding
- chromatin binding
- protein binding
- Protein kinase domain
- sequence-specific DNA binding
- activation loop
- DNA binding
- transcriptional elongation regulator
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- double-stranded DNA binding
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the CDK9 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriatic arthritis
- chronic lymphocytic leukemia
regulated by
- lipopolysaccharide
- STAT3
- adenosine triphosphate
- paroxetine
- human respiratory syncytial virus A2
- geldanamycin
- NEF
- tetradecanoylphorbol acetate
- 26S proteasome
- TCR (complex)
role in cell
- expression in
- production in
- phosphorylation in
- differentiation
- binding in
- apoptosis
- proliferation
- growth
- cell proliferation
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nuclear speckles
- PML nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDK9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- positive regulation by host of viral transcription
- DNA repair
- regulation of DNA repair
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- regulation of mitotic cell cycle
- transcription initiation from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
- positive regulation of transcription elongation from RNA polymerase II promoter
- regulation of muscle cell differentiation
- regulation of mRNA 3'-end processing
- cellular response to cytokine stimulus
- replication fork processing
- regulation of cell cycle
- nucleus localization
Cellular Component
Where in the cell the gene product is active
- dimeric positive transcription elongation factor complex b
- nucleus
- PML body
- transcription elongation factor complex
- membrane
- positive transcription elongation factor complex b
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- RNA polymerase II carboxy-terminal domain kinase activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- protein kinase activity
- cyclin-dependent protein kinase activity
- chromatin binding
- protein serine/threonine kinase activity
- transcription coactivator binding
- DNA binding
- ATP binding
- transcription elongation regulator activity
- protein binding
- kinase activity