BNIP1 Gene Summary [Human]

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]

Details

Type
Protein Coding
Official Symbol
BNIP1
Official Name
BCL2 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:1082]
Ensembl ID
ENSG00000113734
Bio databases IDs NCBI: 662 Ensembl: ENSG00000113734
Aliases BCL2 interacting protein 1
Synonyms 2010005M06RIK, 5930429G21Rik, BCL2/adenovirus E1B interacting protein 1, BCL2 interacting protein 1, Bnip1l1, NIP1, SEC20, TRG-8
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BNIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • SNAP receptor
  • Sec20
  • Bcl-2 homology 3 domain
  • protein binding
  • SNARE motif
  • calcium-release channel
  • transporter

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • primary sclerosing cholangitis
  • open-angle glaucoma
regulated by
  • POU5F1
  • testosterone
  • 12-(3-adamantan-1-yl-ureido) dodecanoic acid
  • bortezomib
role in cell
  • apoptosis
  • fusion
  • formation
  • organization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • intracellular membrane-bounded organelle
  • Golgi Apparatus
  • Endoplasmic Reticulum
  • Mitochondria
  • endoplasmic reticulum membrane
  • mitochondrial membrane
  • mitochondrial outer membrane
  • nuclear envelope

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human BNIP1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • retrograde vesicle-mediated transport, Golgi to ER
  • negative regulation of apoptotic process
  • apoptotic process
  • endoplasmic reticulum membrane fusion
  • calcium-mediated signaling
  • endoplasmic reticulum organization
  • execution phase of apoptosis

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • nuclear envelope
  • mitochondrial membrane
  • cytoplasm
  • intracellular membrane-bounded organelle
  • SNARE complex
  • endoplasmic reticulum
  • mitochondrial outer membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • calcium-induced calcium release activity
  • SNAP receptor activity

Gene-Specific Assays for Results You Can Trust

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