Bnip1 Gene Summary [Mouse]
Predicted to enable SNAP receptor activity and calcium-induced calcium release activity. Predicted to be involved in apoptotic process in response to mitochondrial fragmentation; endoplasmic reticulum membrane fusion; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within apoptotic process. Predicted to be located in several cellular components, including COPI-coated vesicle; mitochondrial membrane; and nuclear envelope. Predicted to be part of SNARE complex. Predicted to be active in endoplasmic reticulum and mitochondrial outer membrane. Orthologous to human BNIP1 (BCL2 interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bnip1 |
| Official Name | BCL2/adenovirus E1B interacting protein 1 [Source:MGI Symbol;Acc:MGI:109328] |
| Ensembl ID | ENSMUSG00000024191 |
| Bio databases IDs | |
| Aliases | BCL2/adenovirus E1B interacting protein 1 |
| Synonyms | 2010005M06RIK, 5930429G21Rik, BCL2/adenovirus E1B interacting protein 1, BCL2 interacting protein 1, Bnip1l1, NIP1, SEC20, TRG-8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bnip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNAP receptor
- Sec20
- Bcl-2 homology 3 domain
- protein binding
- SNARE motif
- calcium-release channel
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondrial outer membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bnip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retrograde vesicle-mediated transport, Golgi to ER
- negative regulation of apoptotic process
- apoptotic process
- endoplasmic reticulum membrane fusion
- calcium-mediated signaling
- endoplasmic reticulum organization
- execution phase of apoptosis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- mitochondrial membrane
- cytoplasm
- intracellular membrane-bounded organelle
- SNARE complex
- endoplasmic reticulum
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium-induced calcium release activity
- SNAP receptor activity