NIT2 Gene Summary [Human]
Enables omega-amidase activity. Involved in asparagine metabolic process; glutamine metabolic process; and oxaloacetate metabolic process. Located in centrosome and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NIT2 |
| Official Name | nitrilase family member 2 [Source:HGNC Symbol;Acc:HGNC:29878] |
| Ensembl ID | ENSG00000114021 |
| Bio databases IDs | |
| Aliases | nitrilase family member 2, omega-amidase NIT2 |
| Synonyms | 1190017B19Rik, D16ERTD502E, HEL-S-8a, nitrilase family member 2, nitrilase family, member 2, RGD1310494 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NIT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nitrilase
- omega-amidase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- Extracellular Space
- organelle lumens
- Nucleus
- centrosome
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NIT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- asparagine metabolic process
- oxaloacetate metabolic process
- glutamine metabolic process
Cellular Component
Where in the cell the gene product is active
- centrosome
- extracellular vesicular exosome
- specific granule lumen
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- omega-amidase activity