BRD4 Gene Summary [Human]
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | BRD4 |
| Official Name | bromodomain containing 4 [Source:HGNC Symbol;Acc:HGNC:13575] |
| Ensembl ID | ENSG00000141867 |
| Bio databases IDs | |
| Aliases | bromodomain containing 4, chromosome-associated protein, mitotic chromosome-associated protein |
| Synonyms | Brd5, bromodomain containing 4, CAP, CDLS6, FSHRG4, HUNK1, HUNKI, LOC100043433, MCAP, WI-11513 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BRD4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- histone binding
- [RNA-polymerase]-subunit kinase
- transcription co-activator
- degron
- nucleic acid binding
- protein binding activity, bridging
- transcription cofactor
- enzyme binding
- chromatin binding
- p53 binding
- extraterminal domain
- Bromodomain extra-terminal - transcription regulation
- protein binding
- Bromodomain
- sequence-specific DNA binding
- DNA binding
- C-terminal domain of bromodomain protein 4
- kinase
- binding protein
- double-stranded DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- neoplastic cell transformation
- tumorigenesis
- hepatic fibrosis
- Cornelia de Lange syndrome type 6
- pulmonary hypertensive arterial disease
- organismal death
- bladder cancer
- hereditary disorder
role in cell
- migration
- expression in
- apoptosis
- proliferation
- quantity
- number
- phosphorylation in
- activation
- activation in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BRD4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of inflammatory response
- positive regulation of T-helper 17 cell lineage commitment
- chromatin organization
- response to DNA damage stimulus
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- RNA polymerase II carboxy-terminal domain kinase activity
- histone acetyl-lysine binding
- transcription regulatory region sequence-specific DNA binding
- chromatin binding
- enzyme binding