BTRC Gene Summary [Human]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | BTRC |
| Official Name | beta-transducin repeat containing E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:1144] |
| Ensembl ID | ENSG00000166167 |
| Bio databases IDs | |
| Aliases | beta-transducin repeat containing E3 ubiquitin protein ligase |
| Synonyms | beta-transducin repeat containing E3 ubiquitin protein ligase, beta-transducin repeat containing protein, BETA-TRCP, beta-TRCP1, b-TrCP, bTrCP1, E3RS-IkappaB, FBW1A, FBXW1, FBXW1A, FWD1, HOS, SCF b-TRCP, Slimb, Trcp β, β-transducin repeat containing E3 ubiquitin protein ligase, β-transducin repeat containing protein, β-TRCP, β-TRCP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BTRC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain superfamily
- beta-catenin binding
- ubiquitin protein ligase activity
- protein binding activity, bridging
- WD domain, G-beta repeat
- WD40
- enzyme
- enzyme regulator activity
- protein binding
- enzyme activator activity
- phosphoprotein amino acid binding
- F-box domain
- D domain of beta-TrCP
- WD40 repeats
- ubiquitin-protein transferase activity
- F-box-like
- substrate binding domain
Pathways
Biological processes and signaling networks where the BTRC gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- prostate cancer
- cancer
- breast cancer
- chromosomal instability
- uterine cancer
- hypoplasia
- organismal death
- epithelial cancer
- epithelial uterine cancer
role in cell
- expression in
- proliferation
- apoptosis
- activation in
- binding in
- degradation in
- survival
- cell death
- transcription in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cytoskeleton
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BTRC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of proteasomal protein catabolic process
- regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of proteolysis
- branching involved in mammary gland duct morphogenesis
- regulation of circadian rhythm
- positive regulation of circadian rhythm
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of canonical Wnt receptor signaling pathway
- mammary gland epithelial cell proliferation
- Wnt receptor signaling pathway
- regulation of cell cycle
- protein K48-linked ubiquitination
- signal transduction
- protein polyubiquitination
- protein dephosphorylation
- NIK/NF-kappaB cascade
- negative regulation of sequence-specific DNA binding transcription factor activity
- negative regulation of smoothened signaling pathway
- ubiquitin-dependent protein catabolic process
- protein destabilization
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of T cell receptor signaling pathway
- rhythmic process
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- cellular response to organic cyclic compound
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphorylated amino acid binding
- protein binding
- protein dimerization activity
- beta-catenin binding
- ligase activity