PLEK Gene Summary [Human]
Enables phosphatidylinositol-3,4-bisphosphate binding activity; protein homodimerization activity; and protein kinase C binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; actin cytoskeleton organization; and positive regulation of supramolecular fiber organization. Located in cytoplasm and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PLEK |
| Official Name | pleckstrin [Source:HGNC Symbol;Acc:HGNC:9070] |
| Ensembl ID | ENSG00000115956 |
| Bio databases IDs | |
| Aliases | pleckstrin |
| Synonyms | 2010300B13Rik, P47, PLECKSTRIN, PLEK1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLEK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DEP
- binding protein
- protein kinase C binding
- PH domain
- protein homodimerization
- phosphatase activator
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- venous thromboembolism
- neonatal late-onset sepsis
- celiac disease
- androgenic alopecia
- COVID-19
- insulin-dependent diabetes mellitus
- thrombocytopenia
- laser induced choroidal neovascularization
- Huntington disease
- Marfan syndrome
regulates
- Myelin
- zymosan
- actin
- inositol phosphate
- Integrin
- 1,4,5-IP3
- INPP5B
role in cell
- activation
- organization
- aggregation
- reorganization
- phagocytosis
- phagocytosis by
- depolymerization
- docking
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cell surface
- Extracellular Space
- cytosol
- membrane ruffles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLEK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of platelet activation
- protein kinase C signaling cascade
- negative regulation of calcium-mediated signaling
- cell projection organization
- regulation of cell diameter
- phosphatidylinositol metabolic process
- negative regulation of G-protein coupled receptor protein signaling pathway
- hemopoietic progenitor cell differentiation
- platelet degranulation
- cortical actin cytoskeleton organization
- thrombin receptor signaling pathway
- integrin-mediated signaling pathway
- phospholipase C-inhibiting G-protein coupled receptor signaling pathway
- positive regulation of actin filament depolymerization
- ruffle organization
- protein secretion by platelet
- positive regulation of inositol-polyphosphate 5-phosphatase activity
- vesicle docking involved in exocytosis
- positive regulation of actin filament bundle assembly
- negative regulation of inositol phosphate biosynthetic process
- positive regulation of integrin activation
- platelet aggregation
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- ruffle membrane
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- protein binding
- protein homodimerization activity
- phosphatidylinositol-3,4-bisphosphate binding