CD40LG Gene Summary [Human]
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CD40LG |
| Official Name | CD40 ligand [Source:HGNC Symbol;Acc:HGNC:11935] |
| Ensembl ID | ENSG00000102245 |
| Bio databases IDs | |
| Aliases | CD40 ligand, CD40 antigen ligand, tumor necrosis factor (ligand) superfamily member 5, T-B cell-activating molecule, TNF-related activation protein, hyper-IgM syndrome |
| Synonyms | CD154, CD40-L, CD40 ligand, gp39, hCD40L, HIGM1, IGM, IMD3, LOC84349, Ly-62, T-BAM, TNFSF5, Tnlg8b, TRAP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD40LG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- CD40 receptor binding
- extracellular domain
- TNF homology domain
- TNF
- integrin binding
- intracellular domain
- TNF-like domain
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the CD40LG gene in human plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Atherosclerosis Signaling
- Autoimmune Thyroid Disease Signaling
- CD40 Signaling
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Dendritic Cell Maturation
- Erythropoietin Signaling
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- IL-17 Signaling
- NF-κB Signaling
- Primary Immunodeficiency Signaling
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Systemic Lupus Erythematosus Signaling
- T Helper Cell Differentiation
- Th1 and Th2 Activation Pathway
- Th1 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- experimental autoimmune encephalomyelitis
- immunodeficiency with hyper-IgM, type 1
- endometriosis
- primary biliary cirrhosis
- colitis
- dilated cardiomyopathy
- hyperplasia
- idiopathic hypereosinophilic syndrome
- rheumatoid arthritis
role in cell
- proliferation
- expression in
- migration
- binding in
- phosphorylation in
- response
- growth
- apoptosis
- generation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- granules
- plasma membrane extracellular face
- cellular protrusions
- perikaryon
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD40LG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- T cell costimulation
- B cell proliferation
- positive regulation of T cell proliferation
- positive regulation of NF-kappaB transcription factor activity
- leukocyte cell-cell adhesion
- CD40 signaling pathway
- inflammatory response
- integrin-mediated signaling pathway
- positive regulation of interleukin-12 production
- negative regulation of apoptotic process
- regulation of immunoglobulin production
- positive regulation of endothelial cell apoptotic process
- positive regulation of interleukin-10 production
- platelet activation
- positive regulation of interleukin-4 production
- isotype switching
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- external side of plasma membrane
- Golgi apparatus
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine kinase activator activity
- protein binding
- CD40 receptor binding
- tumor necrosis factor receptor binding
- integrin binding
- cytokine activity