WDR75 Gene Summary [Human]
Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | WDR75 |
| Official Name | WD repeat domain 75 [Source:HGNC Symbol;Acc:HGNC:25725] |
| Ensembl ID | ENSG00000115368 |
| Bio databases IDs | |
| Aliases | WD repeat domain 75, UTP17, small subunit (SSU) processome component, homolog (yeast) |
| Synonyms | 1300003A18Rik, 2410118I19RIK, C77608, LRRG00118, NET16, UTP17, WD repeat domain 75 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WDR75 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pre-ribosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WDR75 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal small subunit biogenesis
- positive regulation of rRNA processing
- rRNA processing
- positive regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding