MSN Gene Summary [Human]
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MSN |
| Official Name | moesin [Source:HGNC Symbol;Acc:HGNC:7373] |
| Ensembl ID | ENSG00000147065 |
| Bio databases IDs | |
| Aliases | moesin |
| Synonyms | HEL70, IMD50, MOESIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MSN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Band 4.1 homologues
- FERM central domain
- TPR/MLP1/MLP2-like protein
- protein kinase binding
- PspA/IM30 family
- Ezrin/radixin/moesin, alpha-helical domain
- cell adhesion molecule binding
- protein binding activity, bridging
- enzyme binding
- protein binding
- receptor binding
- Pleckstrin homology-like domain
- phosphorylation site
- FERM N-terminal domain
- FERM domain
- structural constituent of cytoskeleton
- actin binding
- Ubl1_cv_Nsp3_N-like
- double-stranded RNA binding
- Ezrin/radixin/moesin family C terminal
- FERM domain B-lobe
- FERM C-terminal PH-like domain
Pathways
Biological processes and signaling networks where the MSN gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- atopic dermatitis
- immunodeficiency 50
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- pervasive developmental disorder
- lymphopenia
- organismal death
- aplastic anemia
role in cell
- expression in
- loss
- phosphorylation in
- quantity
- apoptosis
- invasiveness
- migration
- cell death
- binding
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- detergent-insoluble fractions
- membrane fraction
- cytoskeletal membrane fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- docking structure
- extracellular vesicles
- cytoskeleton
- Cytoplasm
- invadopodia
- cell surface
- cell periphery
- intracellular space
- apical compartment
- perinuclear region
- focal adhesions
- cell cortex
- intercellular junctions
- cell-cell contacts
- cytosol
- apical cell surfaces
- cytoplasmic face of plasma membrane
- membrane ruffles
- apical membrane
- uropod
- basolateral membrane
- nodes of Ranvier
- growth cone
- transverse tubules
- extracellular matrix
- cell tip
- membrane rafts
- brush border
- cleavage furrow
- pseudopodia
- microvilli
- filopodia
- exosomes
- phagocytic cups
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MSN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cytoskeleton organization
- regulation of cell size
- positive regulation of protein catabolic process
- gland morphogenesis
- membrane to membrane docking
- establishment of endothelial barrier
- leukocyte cell-cell adhesion
- immunological synapse formation
- cellular response to testosterone stimulus
- positive regulation of gene expression
- T cell proliferation
- establishment of epithelial cell apical/basal polarity
- T cell aggregation
- T cell migration
- positive regulation of early endosome to late endosome transport
- leukocyte migration
- positive regulation of podosome assembly
- regulation of lymphocyte migration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
- nucleus
- microvillus membrane
- extracellular space
- adherens junction
- extracellular vesicular exosome
- cytoskeleton
- perinuclear region of cytoplasm
- focal adhesion
- uropod
- apical part of cell
- cytoplasm
- microvillus
- blood microparticle
- cytosol
- vesicle
- filopodium
- pseudopodium
- basolateral plasma membrane
- apical plasma membrane
- cell periphery
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- actin binding
- double-stranded RNA binding
- cell adhesion molecule binding
- structural constituent of cytoskeleton
- receptor binding
- enzyme binding