INPP5A Gene Summary [Human]
The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | INPP5A |
| Official Name | inositol polyphosphate-5-phosphatase A [Source:HGNC Symbol;Acc:HGNC:6076] |
| Ensembl ID | ENSG00000068383 |
| Bio databases IDs | |
| Aliases | inositol polyphosphate-5-phosphatase A, CTCL tumor antigen HD-CL-02, 43 kDa inositol polyphosphate 5-phophatase, inositol polyphosphate 5-phophatase, 40kDa, InsP3 5-phosphatase, type I inositol-1,4,5-trisphosphate 5-phosphatase |
| Synonyms | 5PTASE, inositol polyphosphate-5-phosphatase A, LOC100910988, nk6, PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE type I, type I INS(1,4,5)P3 5-PHOSPHATASE |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INPP5A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- inositol-polyphosphate 5-phosphatase
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- phosphatase
- protein binding
- phosphoinositide phosphatase
- PH-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- oligodendroglioma
- hypertension
- liver cancer
- polycystic ovary syndrome
- liver cirrhosis
- glioblastoma
- glioblastoma cancer
- insomnia
- ulcerative colitis
role in cell
- quantity
- survival
- cell death
- assembly
- exocytosis
- firing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- cellular membrane
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INPP5A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
- inositol phosphate metabolic process
- phosphatidylinositol dephosphorylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- inositol-1,4,5-trisphosphate 5-phosphatase activity
- inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
- PH domain binding
- inositol-polyphosphate 5-phosphatase activity