GRIN3B Gene Summary [Human]
The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | GRIN3B |
| Official Name | glutamate ionotropic receptor NMDA type subunit 3B [Source:HGNC Symbol;Acc:HGNC:16768] |
| Ensembl ID | ENSG00000116032 |
| Bio databases IDs | |
| Aliases | glutamate ionotropic receptor NMDA type subunit 3B |
| Synonyms | GluN3B, glutamate ionotropic receptor NMDA type subunit 3B, glutamate receptor, ionotropic, NMDA3B, LOC100508403, NMDAR3B, NR3B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRIN3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neurotransmitter receptor
- glycine binding
- calcium channel
- channel/pore class transporter
- Type 1 periplasmic binding fold superfamily
- Ligated ion channel L-glutamate- and glycine-binding site
- Type 2 periplasmic binding fold superfamily
- ligand-gated ion channel
- extracellular ligand-gated ion channel
- ion channel
- cation channel
- Bacterial extracellular solute-binding proteins, family 3
Pathways
Biological processes and signaling networks where the GRIN3B gene in human plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Calcium Signaling
- Circadian Rhythm Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Ephrin Receptor Signaling
- Glutamate Receptor Signaling
- Neuroinflammation Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- nNOS Signaling in Neurons
- Opioid Signaling Pathway
- Reelin Signaling in Neurons
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- postoperative pain
- anaphylaxis
- epilepsy
- Parkinson disease
- obsessive-compulsive disorder
- multiple sclerosis
- weight gain
- vomiting
- amyotrophic lateral sclerosis
- the common cold
regulates
- Ca2+
- cation
role in cell
- plasticity
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum membrane
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- synapse
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRIN3B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- calcium ion transmembrane transport
- regulation of synaptic transmission
- regulation of calcium ion transport
- ionotropic glutamate receptor signaling pathway
- synaptic transmission, glutamatergic
- protein insertion into membrane
Cellular Component
Where in the cell the gene product is active
- neuronal cell body
- N-methyl-D-aspartate selective glutamate receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- glutamate receptor activity
- calcium channel activity
- cation channel activity
- neurotransmitter receptor activity
- glycine binding
- N-methyl-D-aspartate selective glutamate receptor activity