HSPA5 Gene Summary [Human]
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020]
Details
| Type | Protein Coding |
| Official Symbol | HSPA5 |
| Official Name | heat shock protein family A (Hsp70) member 5 [Source:HGNC Symbol;Acc:HGNC:5238] |
| Ensembl ID | ENSG00000044574 |
| Bio databases IDs | |
| Aliases | heat shock protein family A (Hsp70) member 5, glucose-regulated protein, 78kDa |
| Synonyms | baffled, BIP, D2Wsu141e, D2Wsu17e, GRP 78, HEAT SHOCK 70KDA protein5, heat shock protein 5, heat shock protein family A (Hsp70) member 5, HEL-S-89n, Hsce70, HSP70-5, IDBP2, Immunoglobulin heavy chain binding, mBiP, SEZ-7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HSPA5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- KDEL sequence
- MreB/Mbl protein
- ATP binding
- calcium ion binding
- enzyme binding
- protein domain specific binding
- enzyme
- protein binding
- ATPase
- Fe-S protein assembly chaperone HscA
- nucleotide-binding domain
- protein serine/threonine kinase inhibitor
- chaperone protein DnaK
- ribosome binding
- chaperone binding
- Hsp70 protein
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the HSPA5 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Aldosterone Signaling in Epithelial Cells
- EIF2 Signaling
- Endoplasmic Reticulum Stress Pathway
- eNOS Signaling
- Glucocorticoid Receptor Signaling
- HIF1α Signaling
- Huntington's Disease Signaling
- Natural Killer Cell Signaling
- Protein Ubiquitination Pathway
- Role of PKR in Interferon Induction and Antiviral Response
- Unfolded protein response
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioblastoma
- cancer
- prostate cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- epithelial cancer
- epithelial neoplasia
role in cell
- proliferation
- binding in
- expression in
- migration
- production in
- phosphorylation in
- peroxidation in
- ferroptosis
- growth
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- microsomal fraction
- myelin enriched fraction
- nuclear fraction
- soluble fraction
- endoplasmic reticulum fraction
- low-density microsomal fraction
- detergent-soluble membrane fractions
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- intracellular compartment
- extracellular vesicles
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- vacuole
- Plasma Membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- midbody
- cell-cell contacts
- lipid droplets
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- microsome
- nucleoli
- nuclear rim
- nuclear envelope
- nuclear scaffolds
- dendritic spines
- growth cone
- dendrite initial segments
- neuritic shafts
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- keratohyalin granule
- stress granule
- perikaryon
- dendrites
- dendritic shafts
- dendritic branches
- exosomes
- clathrin-coated vesicles
- phagosomes
- plasma
- phagocytic cups
- endoplasmic reticulum-rich vesicle fraction
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HSPA5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone mediated protein folding requiring cofactor
- cerebellum structural organization
- positive regulation of transcription from RNA polymerase II promoter
- protein refolding
- ER overload response
- cellular response to glucose starvation
- substantia nigra development
- cerebellar Purkinje cell layer development
- regulation of protein folding in endoplasmic reticulum
- endoplasmic reticulum unfolded protein response
- negative regulation of apoptotic process
- cellular response to interleukin-4
- maintenance of protein localization in endoplasmic reticulum
- positive regulation of protein ubiquitination
- negative regulation of protein complex assembly
- posttranslational protein targeting to membrane, translocation
- response to endoplasmic reticulum stress
- negative regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of cell migration
- protein folding in endoplasmic reticulum
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
- cell surface
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- nucleus
- extracellular vesicular exosome
- focal adhesion
- melanosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- mitochondrion
- cytosol
- macromolecular complex
- endoplasmic reticulum chaperone complex
- midbody
- signalosome
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- heat shock protein binding
- protein domain specific binding
- unfolded protein binding
- ATP binding
- protein binding
- protein binding involved in protein folding
- ubiquitin protein ligase binding
- ribosome binding
- cadherin binding
- calcium ion binding
- chaperone binding
- misfolded protein binding
- enzyme binding