NR4A3 Gene Summary [Human]
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | NR4A3 |
| Official Name | nuclear receptor subfamily 4 group A member 3 [Source:HGNC Symbol;Acc:HGNC:7982] |
| Ensembl ID | ENSG00000119508 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 4 group A member 3 |
| Synonyms | AI573420, CHN, CSMF, MINOR, NOR-1, NOR-2, nuclear receptor subfamily 4 group A member 3, nuclear receptor subfamily 4, group A, member 3, TEC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NR4A3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- steroid hormone receptor
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- A/B region
- transcription factor binding
- leucine zipper domain
- AF-2 transcription activation domain
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- DE domain
- AF-1 domain
- ligand-binding domain
- ligand-dependent nuclear receptor
- histone acetyltransferase binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- ligand-dependent nuclear receptor interactor
- protein kinase binding
- DNA binding domain
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- double-stranded DNA binding
- protein homodimerization
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- breast cancer
- obesity
- dyslipidemia
- abdominal aortic aneurysm
- neurological disorder
- systemic lupus erythematosus
- gout
- peripheral T-cell lymphoma
role in cell
- expression in
- phosphorylation in
- production in
- differentiation
- proliferation
- activation in
- growth
- transactivation in
- cell death
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NR4A3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway
- fat cell differentiation
- mast cell degranulation
- positive regulation of transcription from RNA polymerase II promoter
- steroid hormone mediated signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of smooth muscle cell proliferation
- regulation of smooth muscle cell proliferation
- cellular response to corticotropin-releasing hormone stimulus
- cellular response to leptin stimulus
- cellular response to catecholamine stimulus
- energy homeostasis
- positive regulation of cardiac muscle hypertrophy
- positive regulation of feeding behavior
- positive regulation of epithelial cell proliferation
- intracellular signal transduction
- intracellular receptor mediated signaling pathway
- positive regulation of mast cell cytokine production
- platelet-derived growth factor receptor signaling pathway
- cellular respiration
- positive regulation of monocyte aggregation
- gastrulation
- regulation of transcription from RNA polymerase II promoter
- positive regulation of glucose transport
- organ regeneration
- common myeloid progenitor cell proliferation
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- cAMP response element binding
- zinc ion binding
- protein homodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- steroid hormone receptor activity
- glucocorticoid receptor binding