TAL1 Gene Summary [Human]
Enables several functions, including DNA-binding transcription factor activity; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including myeloid cell differentiation; positive regulation of cellular component organization; and positive regulation of erythrocyte differentiation. Located in chromatin and nucleoplasm. Part of transcription regulator complex. Implicated in acute lymphoblastic leukemia. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TAL1 |
| Official Name | TAL bHLH transcription factor 1, erythroid differentiation factor [Source:HGNC Symbol;Acc:HGNC:11556] |
| Ensembl ID | ENSG00000162367 |
| Bio databases IDs | |
| Aliases | TAL bHLH transcription factor 1, erythroid differentiation factor |
| Synonyms | bHLHa17, Hpt, SCL, SCL/tal-1, TAL-1/SCL, TAL bHLH transcription factor 1, erythroid differentiation factor, T cell acute lymphocytic leukaemia 1, T cell acute lymphocytic leukemia 1, TCL5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- enzyme binding
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- helix loop helix domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- thymus cancer
- lymphoid cancer
- mediastinal cancer
- lymphatic neoplasia
- lymphomagenesis
- thoracic cancer
- hematologic cancer
- hematological neoplasia
- severe acute respiratory syndrome
role in cell
- expression in
- activation in
- formation
- cell viability
- apoptosis
- survival
- cell cycle progression
- lack
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic hemopoiesis
- hemopoiesis
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of erythrocyte differentiation
- erythrocyte maturation
- negative regulation of transcription from RNA polymerase II promoter
- locomotory behavior
- positive regulation of cell division
- positive regulation of transcription, DNA-dependent
- angiogenesis
- platelet formation
- megakaryocyte development
- basophil differentiation
- positive regulation of protein complex assembly
- regulation of mast cell differentiation
- spinal cord association neuron differentiation
- hemangioblast cell differentiation
- hemopoietic stem cell differentiation
- regulation of cell proliferation
- positive regulation of mitotic cell cycle
- astrocyte fate commitment
- definitive hemopoiesis
- regulation of transcription from RNA polymerase II promoter
- megakaryocyte differentiation
- erythrocyte differentiation
- cell fate commitment
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- histone deacetylase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- protein dimerization activity
- chromatin binding
- enzyme binding
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity