ACOT2 Gene Summary [Human]
This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | ACOT2 |
| Official Name | acyl-CoA thioesterase 2 [Source:HGNC Symbol;Acc:HGNC:18431] |
| Ensembl ID | ENSG00000119673 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 2, mitochondrial acyl-CoA thioesterase 1 |
| Synonyms | acyl-CoA thioesterase 2, CTE1A, CTE-IA, MTE1, PTE2, PTE2A, ZAP128 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACOT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyl-CoA hydrolase
- thiolester hydrolase
- alpha/beta hydrolases
- Acyl-CoA thioester hydrolase/BAAT N-terminal region
- enzyme
- protein binding
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- Mitochondria
- cytosol
- mitochondrial matrix
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACOT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- long-chain fatty acid metabolic process
- very long-chain fatty acid metabolic process
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- acyl-CoA hydrolase activity
- carboxylic ester hydrolase activity