ACOT1 Gene Summary [Human]
Enables acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and very long-chain fatty acid metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ACOT1 |
| Official Name | acyl-CoA thioesterase 1 [Source:HGNC Symbol;Acc:HGNC:33128] |
| Ensembl ID | ENSG00000184227 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 1 |
| Synonyms | ACH2, Acot3, acyl-CoA thioesterase 1, acyl-CoA thioesterase 3, AW108394, CTE-1, LACH2, Pte2a, PTE-Ia, RGD1564089 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACOT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyl-CoA hydrolase
- thiolester hydrolase
- alpha/beta hydrolases
- Acyl-CoA thioester hydrolase/BAAT N-terminal region
- enzyme
- protein binding
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- breast cancer
- squamous-cell carcinoma
- squamous cell cancer
- hepatocellular carcinoma
- cardiomyopathy
- renal clear cell adenocarcinoma
- renal clear cell cancer
- diabetic nephropathy
regulates
- acyl-coenzyme A
- long chain fatty acid
- very long chain fatty acid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACOT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- long-chain fatty acid metabolic process
- very long-chain fatty acid metabolic process
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- acyl-CoA hydrolase activity
- carboxylic ester hydrolase activity