GPR31 Gene Summary [Human]
Enables G protein-coupled receptor activity and arachidonic acid binding activity. Involved in G protein-coupled receptor signaling pathway and response to acidic pH. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GPR31 |
| Official Name | G protein-coupled receptor 31 [Source:HGNC Symbol;Acc:HGNC:4486] |
| Ensembl ID | ENSG00000120436 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 31, hydroxyeicosatetraenoic (HETE) acid receptor 1, 12-(S)-HETE acid receptor |
| Synonyms | 12-HETER, Gpr31b, Gpr31c, GPR31c(t), G protein-coupled receptor 31, G protein-coupled receptor 31, D17Leh66b region, HETER, HETER1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR31 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- bioactive lipid receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- arachidonic acid binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPR31 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPR31 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to molecule of bacterial origin
- response to ischemia
- G-protein coupled receptor signaling pathway
- negative regulation of inflammatory response
- lipid metabolic process
- response to acidity
- positive regulation of immune response
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- bioactive lipid receptor activity
- arachidonic acid binding