TAF1L Gene Summary [Human]
This locus is intronless, and apparently arose in the primate lineage from retrotransposition of the transcript from the multi-exon TAF1 locus on the X chromosome. The gene is expressed in male germ cells, and the product has been shown to function interchangeably with the TAF1 product. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | TAF1L |
| Official Name | TATA-box binding protein associated factor 1 like [Source:HGNC Symbol;Acc:HGNC:18056] |
| Ensembl ID | ENSG00000122728 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 1 like |
| Synonyms | TAF2A2, TAF(II)210, TATA-box binding protein associated factor 1 like |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAF1L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc knuckle
- TATA box-binding protein binding
- protein serine/threonine kinase
- histone binding
- transcription regulator
- protein kinase
- histone acetyltransferase
- protein binding
- Bromodomain
- TATA-binding protein binding
- Protein of unknown function (DUF3591)
Pathways
Biological processes and signaling networks where the TAF1L gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAF1L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA polymerase II transcriptional preinitiation complex assembly
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- male meiosis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor TFIID complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- histone acetyltransferase activity
- general RNA polymerase II transcription factor activity
- histone acetyl-lysine binding
- TBP-class protein binding
- protein serine/threonine kinase activity