ABCC10 Gene Summary [Human]
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | ABCC10 |
| Official Name | ATP binding cassette subfamily C member 10 [Source:HGNC Symbol;Acc:HGNC:52] |
| Ensembl ID | ENSG00000124574 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily C member 10 |
| Synonyms | ATP binding cassette subfamily C member 10, ATP-binding cassette, sub-family C member 10, EST182763, mFLJ00002, MRP7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ABCC10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase activity, coupled to transmembrane movement of substances
- lipid A export permease/ATP-binding protein MsbA
- conjugate transporter
- inorganic anion transporter
- heme ABC exporter, ATP-binding protein CcmA
- ABC transporter transmembrane region
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- thiol reductant ABC exporter, CydD subunit
- cystic fibrosis transmembrane conductor regulator (CFTR)
- thiol reductant ABC exporter, CydC subunit
- xenobiotic-transporting ATPase
- multi drug resistance-associated protein (MRP)
- ABC transporter
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the ABCC10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- major depression
- organismal death
- non-insulin-dependent diabetes mellitus
- hepatocellular carcinoma
- liver cancer
- Alzheimer disease
- endometrial cancer
- neutropenia
- coronary artery disease
regulates
- MAPT
- taxane
- epothilone
- docetaxel
- monohexosylceramide
- 18:0 hexosylceramide
- paclitaxel
- leukotriene
- 24:1 hexosylceramide
- 26:0 hexosylceramide
role in cell
- synthesis in
- accumulation in
- cell viability
- quantity
- proliferation
- number
- lysis
- invasion by
- transport in
- paclitaxel sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- basolateral membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ABCC10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- leukotriene transport
- transmembrane transport
- leukotriene metabolic process
- xenobiotic transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- membrane
- basolateral plasma membrane
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of substances
- glutathione S-conjugate-exporting ATPase activity
- xenobiotic-transporting ATPase activity
- anion transmembrane-transporting ATPase activity