AVPR1B
AVPR1B Gene Summary
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | AVPR1B |
| Official Name | arginine vasopressin receptor 1B [Source:HGNC Symbol;Acc:HGNC:896] |
| Ensembl ID | ENSG00000198049 |
| Bio databases IDs | |
| Aliases | arginine vasopressin receptor 1B, V1B receptor, Vasopressin V3 receptor |
| Synonyms | arginine vasopressin receptor 1B,AVPR3,AVPR V1b,AVPR V3,V1bR,V3/V1b,VIBR,VPR3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- vasopressin receptor
- protein kinase C binding
- 7 transmembrane receptor (rhodopsin family)
- Vasopressin V1 receptor, C-terminal
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the AVPR1B gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PIK3CA
- CRHR1
- desmopressin
- ABCC10
- KLRG2
- CANX
- OSBPL8
- AVP
- lypressin
- SLC35F5
disease
- von Willebrand disease
- vasodilatory shock
- diabetes insipidus
- cardiac arrest
- polycystic kidney disease
- septic shock
- sepsis
- bleeding
regulated by
- tetradecanoylphorbol acetate
- dexamethasone
- AVP
- nelivaptan
- [deamino1, Leu4, Lys8] vasopressin
- hydrocortisone
- Trl
- lypressin
- cycloheximide
- CRHR1
regulates
- Ca2+
- proinsulin
- L-glutamic acid
- PLA2
- corticosterone
- POMC
- astressin
- CRHR1
- testosterone
- inositol phosphate
role in cell
- proliferation
- quantity
- elevation in
- entrance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- cellular membrane
- endosomes
- Golgi Apparatus
- cytoplasmic vesicles
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the AVPR1B gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- viral entry into host cell
- positive regulation of arachidonic acid secretion
- G-protein coupled receptor signaling pathway
- positive regulation of vasoconstriction
- cellular response to hormone stimulus
- positive regulation of phospholipase A2 activity
- positive regulation of MAPK cascade
- regulation of cell proliferation
- positive regulation of inositol phosphate biosynthetic process
- elevation of cytosolic calcium ion concentration
- regulation of systemic arterial blood pressure by vasopressin
CELLULAR COMPONENT
Where in the cell the gene product is active
- endosome
- Golgi apparatus
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein kinase C binding
- vasopressin receptor activity
- peptide binding