NEAT1 Gene Summary [Human]
This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | NEAT1 |
| Official Name | nuclear paraspeckle assembly transcript 1 [Source:HGNC Symbol;Acc:HGNC:30815] |
| Ensembl ID | ENSG00000245532 |
| Bio databases IDs | |
| Aliases | nuclear paraspeckle assembly transcript 1, trophoblast derived non-protein coding RNA, nuclear enriched abundant transcript 1, long intergenic non-protein coding RNA 84, virus inducible non-coding RNA |
| Synonyms | 2310043N10Rik, CR618687, FLJ23538, LINC00084, LOC100292444, MEN epsilon/beta, MEN ε/β, NCRNA00084, nuclear paraspeckle assembly transcript 1, nuclear paraspeckle assembly transcript 1 (non-protein coding), TncRNA, TP53LC15, VINC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEAT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- ribonucleoprotein binding
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- non-small cell lung cancer
- cancer
- neoplasia
- schizophrenia
- skin cancer
- gastric cancer
- liver cancer
- glioblastoma
- acute myeloid leukemia
role in cell
- phosphorylation in
- apoptosis
- cell viability
- expression in
- proliferation
- formation in
- cell death
- G1 phase
- abnormal morphology
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular space
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEAT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gene silencing by miRNA
- positive regulation of inflammatory response
- positive regulation of miRNA catabolic process
- regulation of mRNA export from nucleus
- nuclear body organization
Cellular Component
Where in the cell the gene product is active
- paraspeckles
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- miRNA binding