TOP3B Gene Summary [Human]
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | TOP3B |
| Official Name | DNA topoisomerase III beta [Source:HGNC Symbol;Acc:HGNC:11993] |
| Ensembl ID | ENSG00000100038 |
| Bio databases IDs | |
| Aliases | DNA topoisomerase III beta |
| Synonyms | DNA topoisomerase III beta, DNA topoisomerase III β, TOP3B1, TOP3 β, TOPO3, Topo III β, topoisomerase (DNA) III beta, topoisomerase (DNA) III β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TOP3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA topoisomerase type I
- Bacterial DNA topoisomeraes I ATP-binding domain
- Bacterial DNA topoisomerase I DNA-binding domain
- DNA topoisomerase
- TOP1Ac
- TOPRIM
- isomerase
- Toprim domain
- topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins
- enzyme
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TOP3B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA recombination
- chromosome segregation
- DNA topological change
Cellular Component
Where in the cell the gene product is active
- condensed chromosome
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- DNA topoisomerase activity
- DNA topoisomerase type I activity