SLURP1 Gene Summary [Human]
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLURP1 |
| Official Name | secreted LY6/PLAUR domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18746] |
| Ensembl ID | ENSG00000126233 |
| Bio databases IDs | |
| Aliases | secreted LY6/PLAUR domain containing 1, lymphocyte antigen 6-like secreted, ARS component B |
| Synonyms | 1110021N19Rik, ANUP, ARS, ArsB, LY6LS, LY6-MT, MDM, RGD1308768, secreted LY6/PLAUR domain containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLURP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylcholine receptor agonist
- protein binding
- cytokine
- TFP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acroerythrokeratoderma
- lichen planus
- obesity
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- gait disturbance
regulates
- triacylglycerol
- cholesterol
- LEP
- carbon dioxide
- oxygen
- Ins1
role in cell
- proliferation
- migration
- growth
- adhesion
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLURP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of keratinocyte proliferation
- neuromuscular process controlling posture
- cell activation
- locomotory behavior
- negative regulation of cell proliferation
- cell adhesion
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- acetylcholine receptor activator activity
- protein binding
- cytokine activity