Slurp1 Gene Summary [Mouse]
Predicted to enable acetylcholine receptor activator activity. Acts upstream of or within several processes, including locomotory behavior; negative regulation of keratinocyte proliferation; and neuromuscular process controlling posture. Predicted to be located in extracellular space. Is expressed in cornea; ductus deferens; prostate gland; and testis. Used to study mal de Meleda. Human ortholog(s) of this gene implicated in mal de Meleda and palmoplantar keratosis. Orthologous to human SLURP1 (secreted LY6/PLAUR domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slurp1 |
| Official Name | secreted Ly6/Plaur domain containing 1 [Source:MGI Symbol;Acc:MGI:1930923] |
| Ensembl ID | ENSMUSG00000022596 |
| Bio databases IDs | |
| Aliases | secreted Ly6/Plaur domain containing 1 |
| Synonyms | 1110021N19Rik, ANUP, ARS, ArsB, LY6LS, LY6-MT, MDM, RGD1308768, secreted LY6/PLAUR domain containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slurp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylcholine receptor agonist
- protein binding
- cytokine
- TFP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acroerythrokeratoderma
- lichen planus
- obesity
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- gait disturbance
regulated by
- PAGA
- SOS
- budesonide
- FOS
role in cell
- proliferation
- migration
- growth
- adhesion
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slurp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of keratinocyte proliferation
- neuromuscular process controlling posture
- cell activation
- locomotory behavior
- negative regulation of cell proliferation
- cell adhesion
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- acetylcholine receptor activator activity
- protein binding
- cytokine activity