GID8 Gene Summary [Human]
Predicted to enable protein homodimerization activity. Involved in positive regulation of canonical Wnt signaling pathway and positive regulation of cell population proliferation. Located in cell junction; cytosol; and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GID8 |
| Official Name | GID complex subunit 8 homolog [Source:HGNC Symbol;Acc:HGNC:15857] |
| Ensembl ID | ENSG00000101193 |
| Bio databases IDs | |
| Aliases | GID complex subunit 8 homolog, two hybrid associated protein No. 1 with RanBPM |
| Synonyms | 2310003C23Rik, 4833420G11Rik, Bwk1, C20orf11, GID complex subunit 8, GID complex subunit 8 homolog, LOC284734, TWA1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GID8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CTLH/CRA C-terminal to LisH motif domain
- CT11-RanBPM
- protein homodimerization
- C-terminal to LisH motif
- protein binding
- LisH
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GID8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of cell proliferation
- positive regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- cytosol
- cell junction
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding