TSKS Gene Summary [Human]
This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | TSKS |
| Official Name | testis specific serine kinase substrate [Source:HGNC Symbol;Acc:HGNC:30719] |
| Ensembl ID | ENSG00000126467 |
| Bio databases IDs | |
| Aliases | testis specific serine kinase substrate, protein phosphatase 1, regulatory subunit 161 |
| Synonyms | PPP1R161, STK22S1, testis-specific serine kinase substrate, TSKS1, TSSKS, Tssks1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TSKS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Testis-specific serine kinase substrate
- protein kinase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- reticulated body
- chromatoid body remnant
- centriole
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TSKS gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- centriole
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding