ADM2 Gene Summary [Human]
This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]
Details
| Type | Protein Coding |
| Official Symbol | ADM2 |
| Official Name | adrenomedullin 2 [Source:HGNC Symbol;Acc:HGNC:28898] |
| Ensembl ID | ENSG00000128165 |
| Bio databases IDs | |
| Aliases | adrenomedullin 2 |
| Synonyms | adrenomedullin 2, AM2, dJ579N16.4, IMD, Imdn, INTERMEDIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- hormone
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- spontaneous hypertension
- non-small cell lung cancer
- obesity
- small cell lung cancer
- insulin resistance
role in cell
- expression in
- quantity
- number
- activation in
- morphology
- phosphorylation in
- function
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of heart rate
- angiogenesis
- positive regulation of gene expression
- regulation of systemic arterial blood pressure
- feeding behavior
- negative regulation of blood pressure
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- protein phosphorylation
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- hormone activity