CALCRL Gene Summary [Human]
Enables adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to sucrose stimulus; and receptor internalization. Located in endoplasmic reticulum; endosome; and lysosome. Part of CGRP receptor complex and adrenomedullin receptor complex. Colocalizes with plasma membrane. Implicated in hereditary lymphedema. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CALCRL |
| Official Name | calcitonin receptor like receptor [Source:HGNC Symbol;Acc:HGNC:16709] |
| Ensembl ID | ENSG00000064989 |
| Bio databases IDs | |
| Aliases | calcitonin receptor like receptor |
| Synonyms | calcitonin receptor-like, calcitonin receptor like receptor, CGRPR, CGRP Receptor, CGRP type 1 receptor, CLR, Crl, CRLR, LMPHM8, RATCRLR, RNCLR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CALCRL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- calcitonin gene-related polypeptide receptor
- adrenomedullin receptor
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the CALCRL gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- edema
- migraines
- obesity
- hydrops fetalis
- COVID-19
- metabolic syndrome X
- migraine with or without aura
- organismal death
- renal cell carcinoma
role in cell
- expression in
- activation in
- proliferation
- migration
- apoptosis
- number
- production in
- growth
- binding
- loss in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- endosomes
- vesicles
- lysosome
- Endoplasmic Reticulum
- acrosome
- synaptic vesicles
- secretory granules
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CALCRL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- angiogenesis
- calcium ion transport
- protein transport
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cellular response to sucrose stimulus
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- endosome
- cytoplasm
- endoplasmic reticulum
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- calcitonin gene-related polypeptide receptor activity
- calcitonin receptor activity
- adrenomedullin receptor activity