SAP30 Gene Summary [Human]
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | SAP30 |
| Official Name | Sin3A associated protein 30 [Source:HGNC Symbol;Acc:HGNC:10532] |
| Ensembl ID | ENSG00000164105 |
| Bio databases IDs | |
| Aliases | Sin3A associated protein 30 |
| Synonyms | Sin3A associated protein 30, sin3 associated polypeptide |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SAP30 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- silencing domain
- transcription regulator
- SAP30 zinc-finger
- amphipathic helix
- transcription co-repressor
- histone deacetylase binding domain
- protein binding
- Sin3 binding region of histone deacetylase complex subunit SAP30
Pathways
Biological processes and signaling networks where the SAP30 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- metastasis
- chromosomal instability
- HER2-positive breast cancer
- estrogen receptor positive breast cancer
- HER2 negative hormone receptor negative breast cancer
- sarcoidosis
role in cell
- expression in
- differentiation
- repression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SAP30 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- skeletal muscle cell differentiation
- modulation by host of symbiont transcription
- regulation of transcription, DNA-dependent
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- histone deacetylase complex
- nucleoplasm
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- transcription cofactor activity
- protein binding
- transcription corepressor activity
- metal ion binding