TAS2R16
TAS2R16 Gene Summary
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TAS2R16 |
| Official Name | taste 2 receptor member 16 [Source:HGNC Symbol;Acc:HGNC:14921] |
| Ensembl ID | ENSG00000128519 |
| Bio databases IDs | |
| Aliases | taste 2 receptor member 16 |
| Synonyms | BGLPT,Gm465,mGR18,mt2r40,T2R16,T2R18,T2R3,Tas2r118,Tas2r18,taste 2 receptor member 16,taste receptor, type 2, member 118 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- taste receptor
- Taste receptor protein (TAS2R)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the TAS2R16 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- arbutin
- phenylglucoside
- salicin
- RTP4
- RTP3
disease
- alcoholism
regulated by
- RTP3
- RTP4
- salicin
regulates
- HAMP
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
- plasma membrane extracellular face
- trans Golgi network
- cis Golgi cisternae
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TAS2R16 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- detection of chemical stimulus involved in sensory perception of bitter taste
CELLULAR COMPONENT
Where in the cell the gene product is active
- trans-Golgi network
- membrane
- external side of plasma membrane
- endoplasmic reticulum
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- bitter taste receptor activity