Tas2r118 Gene Summary [Mouse]
Predicted to enable bitter taste receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste. Predicted to be located in endoplasmic reticulum; external side of plasma membrane; and trans-Golgi network. Predicted to be active in membrane. Is expressed in circumvallate papillae; colon; and jejunum. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human TAS2R16 (taste 2 receptor member 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tas2r118 |
| Official Name | taste receptor, type 2, member 118 [Source:MGI Symbol;Acc:MGI:2681247] |
| Ensembl ID | ENSMUSG00000043865 |
| Bio databases IDs | |
| Aliases | taste receptor, type 2, member 118 |
| Synonyms | BGLPT, Gm465, mGR18, mt2r40, T2R16, T2R18, T2R3, Tas2r118, Tas2r18, taste 2 receptor member 16, taste receptor, type 2, member 118 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tas2r118 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- taste receptor
- Taste receptor protein (TAS2R)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Tas2r118 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
- plasma membrane extracellular face
- trans Golgi network
- cis Golgi cisternae
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tas2r118 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- detection of chemical stimulus involved in sensory perception of bitter taste
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- membrane
- external side of plasma membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- bitter taste receptor activity