GGACT Gene Summary [Human]
The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a free alkylamine. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | GGACT |
| Official Name | gamma-glutamylamine cyclotransferase [Source:HGNC Symbol;Acc:HGNC:25100] |
| Ensembl ID | ENSG00000134864 |
| Bio databases IDs | |
| Aliases | gamma-glutamylamine cyclotransferase |
| Synonyms | A2LD1, gamma-glutamylamine cyclotransferase, γ-glutamylamine cyclotransferase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GGACT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amidine lyase
- GGCT_like
- enzyme
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GGACT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular modified amino acid catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding