COPS7B
COPS7B Gene Summary
Involved in protein deneddylation. Located in nucleoplasm. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | COPS7B |
| Official Name | COP9 signalosome subunit 7B [Source:HGNC Symbol;Acc:HGNC:16760] |
| Ensembl ID | ENSG00000144524 |
| Bio databases IDs | |
| Aliases | COP9 signalosome subunit 7B |
| Synonyms | COP9 signalosome subunit 7B,CSN7B,D1Wsu66e,E130114M23,SGN7b |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- COP9 signalosome complex subunit 7a helix I domain
- protein binding
Pathways
Biological processes and signaling networks where the COPS7B gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- H2AC20
- DIABLO
- CUL4A
- TRIM67
- EWSR1
- COPS2
- COPS8
- CRBN
- RPA3
- COPS3
disease
- neoplasia
- colorectal cancer
- metastasis
- aortic valve calcification
regulated by
- bucladesine
- PPARD
- IGF2BP3
- H1-6
- H1-1
regulates
- METTL5
- RPS6KB1
- EIF4EBP1
- RNR
- NPM1
- NMD3
- RPL6
- CDKN1B
role in cell
- expression in
- phosphorylation in
- CSN5i-3 sensitivity
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the COPS7B gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- protein deneddylation
- signalosome assembly
- regulation of protein neddylation
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- signalosome
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding