FPGS Gene Summary [Human]
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
Details
| Type | Processed Transcript |
| Official Symbol | FPGS |
| Official Name | folylpolyglutamate synthase [Source:HGNC Symbol;Acc:HGNC:3824] |
| Ensembl ID | ENSG00000136877 |
| Bio databases IDs | |
| Aliases | folylpolyglutamate synthase |
| Synonyms | folylpolyglutamate synthase, folylpolyglutamyl synthetase, folylpoly γ glutamate synthetase, LOC103691767 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FPGS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mur ligase family, glutamate ligase domain
- tetrahydrofolylpolyglutamate synthase
- PLN02881
- enzyme
- folylpolyglutamate synthase/dihydrofolate synthase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Sézary syndrome
- rheumatoid arthritis
- large cell transformed mycosis fungoides
- CD30 positive anaplastic large cell lymphoma
- angioimmunoblastic T-cell lymphoma
- Dukes stage C colorectal cancer
- peripheral T-cell lymphoma
- relapsed peripheral T-cell lymphoma
- hepatosplenic T-cell lymphoma
- nasal type extranodal NK-/T-cell lymphoma
regulates
- L-glutamic acid
- folic acid and derivative
- folic acid
- tetrahydrofolylpolyglutamate
- methotrexate polyglutamate
- methotrexate
- nucleic acid component or derivative
role in cell
- proliferation
- growth
- survival
- reverse transcription in
- reverse transcription
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FPGS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamate metabolic process
- liver development
- folic acid metabolic process
- organ regeneration
- folic acid-containing compound metabolic process
- tetrahydrofolylpolyglutamate biosynthetic process
- nucleobase-containing compound metabolic process
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytoplasm
- mitochondrion
- cytosol
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- tetrahydrofolylpolyglutamate synthase activity
- ATP binding
- metal ion binding