LAMP2 Gene Summary [Human]
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LAMP2 |
| Official Name | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] |
| Ensembl ID | ENSG00000005893 |
| Bio databases IDs | |
| Aliases | lysosomal associated membrane protein 2 |
| Synonyms | CD107b, DND, Lamp-2b, Lamp-2c, LAMPB, Lamp II, LGP110, LGP-96, LGP-B, lysosomal-associated membrane protein 2, Mac3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LAMP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ion channel inhibitor
- Lysosome-associated membrane glycoprotein (Lamp)
- transmembrane domain
- protein binding activity, bridging
- TM_EGFR-like
- enzyme binding
- protein domain specific binding
- protein binding
- cytosolic tail domain
- enzyme
Pathways
Biological processes and signaling networks where the LAMP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- glioblastoma
- colon cancer
- danon disease
- Huntington disease
- chronic obstructive pulmonary disease
- coronary artery disease
- non-insulin-dependent diabetes mellitus
- hypertrophic cardiomyopathy
- glioblastoma cancer
role in cell
- formation
- phosphorylation in
- production in
- apoptosis
- cell viability
- expression in
- cell death
- degradation in
- accumulation in
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- multivesicular domain
- early endosome-associated tubule
- endoplasmic reticulum mitochondria contact site
- intracellular membrane-bounded organelle
- lysosome matrix
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- microvesicles
- membrane surface
- cellular membrane
- multilamellar bodies
- endosomes
- vesicles
- lysosome
- secretory granule membrane
- granules
- vesicle membrane
- microdomains
- trans Golgi network
- endosome-lysosome compartments
- lysosome membrane
- lysosomal compartment
- endosomal membrane
- acrosome
- cytotoxic granule
- autophagic vacuoles
- late endosomes
- cytoplasmic vesicles
- melanosomes
- multivesicular bodies
- autolysosomes
- membrane rafts
- exosomes
- phagosomes
- late endosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LAMP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- muscle cell homeostasis
- regulation of protein stability
- lysosomal lumen acidification
- cellular response to starvation
- protein stabilization
- protein import
Cellular Component
Where in the cell the gene product is active
- late endosome
- lysosomal lumen
- plasma membrane
- autophagic vacuole membrane
- lysosomal membrane
- lysosome
- late endosome membrane
- extracellular space
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- phagocytic vesicle membrane
- platelet dense granule membrane
- azurophil granule membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- ion channel inhibitor activity
- enzyme binding