GPR174 Gene Summary [Human]

This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]

Details

Type
Protein Coding
Official Symbol
GPR174
Official Name
G protein-coupled receptor 174 [Source:HGNC Symbol;Acc:HGNC:30245]
Ensembl ID
ENSG00000147138
Bio databases IDs NCBI: 84636 Ensembl: ENSG00000147138
Aliases G protein-coupled receptor 174
Synonyms FKSG79, Gm376, GPCR17, G protein-coupled receptor 174, LOC107985690, LPS3, LYPSR3, RGD1564689
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR174 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor
  • bioactive lipid receptor
  • Cholecystokinin A receptor, N-terminal
  • 7 transmembrane receptor (rhodopsin family)
  • seven-transmembrane G protein-coupled receptor superfamily

Pathways

Biological processes and signaling networks where the GPR174 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • Graves disease
  • Ewing sarcoma
  • osteosarcomagenesis
  • experimental autoimmune encephalomyelitis
regulated by
role in cell
  • proliferation
  • expression in
  • survival
  • generation
  • homeostasis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • intracellular membrane-bounded organelle
  • cellular membrane
  • centrosome

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human GPR174 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of interleukin-2 production
  • positive regulation of Rho protein signal transduction
  • phospholipase C-activating G-protein coupled receptor signaling pathway
  • T cell homeostasis

Cellular Component

Where in the cell the gene product is active
  • intracellular membrane-bounded organelle
  • centriolar satellite
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • G-protein coupled receptor activity
  • bioactive lipid receptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.