ARHGEF39 Gene Summary [Human]
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | ARHGEF39 |
| Official Name | Rho guanine nucleotide exchange factor 39 [Source:HGNC Symbol;Acc:HGNC:25909] |
| Ensembl ID | ENSG00000137135 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor 39 |
| Synonyms | C9orf100, E130306D19Rik, RGD1310376, Rho guanine nucleotide exchange factor 39 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARHGEF39 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- PH domain
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
Pathways
Biological processes and signaling networks where the ARHGEF39 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARHGEF39 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity