FARSA Gene Summary [Human]
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FARSA |
| Official Name | phenylalanyl-tRNA synthetase subunit alpha [Source:HGNC Symbol;Acc:HGNC:3592] |
| Ensembl ID | ENSG00000179115 |
| Bio databases IDs | |
| Aliases | phenylalanyl-tRNA synthetase subunit alpha, phenylalanine tRNA ligase 1, alpha, cytoplasmic |
| Synonyms | 0610012A19Rik, CML33, FARSL, FARSLA, FRSA, PheHA, Phenylalanine-tRNA synthetase-like, alpha-subunit, Phenylalanine-tRNA synthetase-like, α-subunit, phenylalanyl-tRNA synthetase, alpha subunit, phenylalanyl-tRNA synthetase subunit alpha, phenylalanyl-tRNA synthetase subunit α, phenylalanyl-tRNA synthetase, α subunit, pheRS, RILDBC2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FARSA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PheRS DNA binding domain 3
- class_II_aaRS-like_core
- phenylalanyl-tRNA synthetase, alpha subunit
- HTH domain
- HTH_ARSR
- PheRS DNA binding domain 1
- enzyme
- protein binding
- magnesium ion binding
- HTH_CRP
- PheRS DNA binding domain 2
- phenylalanine-tRNA ligase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Rajab interstitial lung disease with brain calcifications 2
role in cell
- activation in
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell cortex
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FARSA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phenylalanyl-tRNA aminoacylation
- protein heterotetramerization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- phenylalanine-tRNA ligase complex
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- RNA binding
- protein binding
- phenylalanine-tRNA ligase activity
- tRNA binding