BMP2K Gene Summary [Human]
This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | BMP2K |
| Official Name | BMP2 inducible kinase [Source:HGNC Symbol;Acc:HGNC:18041] |
| Ensembl ID | ENSG00000138756 |
| Bio databases IDs | |
| Aliases | BMP2 inducible kinase |
| Synonyms | 4933417M22Rik, BIKE, BMP-2 inducible kinase, HRIHFB2017, LOC289485 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BMP2K often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- phosphatase regulator
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- BMP-2-inducible protein kinase C-terminus
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- productive infection by HIV-1
role in cell
- activation
- stabilization in
- stabilization
- fludarabine resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BMP2K gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Notch signaling pathway
- regulation of clathrin-mediated endocytosis
- regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
Molecular Function
What the gene product does at the molecular level
- ATP binding
- phosphatase regulator activity
- protein binding
- protein serine/threonine kinase activity
- AP-2 adaptor complex binding