IGF1 Gene Summary [Human]
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | IGF1 |
| Official Name | insulin like growth factor 1 [Source:HGNC Symbol;Acc:HGNC:5464] |
| Ensembl ID | ENSG00000017427 |
| Bio databases IDs | |
| Aliases | insulin like growth factor 1, somatomedin C |
| Synonyms | C730016P09Rik, IGF, IGF-I, IGF-I-smC, INSULIN-LIKE GROWTH FACTOR 1, insulin like growth factor I, insulin-like somatomedin peptide I, MAD isoform 4, mecasermin, mecasermin recombinant, MGF, Preproinsulin-like growth factor ia, somatomedin C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- insulin like growth factor C domain
- insulin like growth factor D domain
- insulin receptor binding
- hormone
- protein binding
- cytokine
- insulin-like growth factor receptor binding
- growth factor
- steroid binding
- protein kinase activator
- kinase domain
- transmembrane receptor protein tyrosine kinase activator
- insulin like growth factor B domain
- insulin like growth factor A domain
- Insulin/IGF/Relaxin family
- integrin binding
- intracellular domain
- IlGF_like
- receptor agonist activity
Pathways
Biological processes and signaling networks where the IGF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Autophagy
- Cardiac Hypertrophy Signaling
- Clathrin-mediated Endocytosis Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Ephrin A Signaling
- Estrogen Receptor Signaling
- Estrogen-Dependent Breast Cancer Signaling
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- IGF-1 Signaling
- RhoA Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of JAK2 in Hormone-like Cytokine Signaling
- Role of NFAT in Cardiac Hypertrophy
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- STAT3 Pathway
- Thyroid Cancer Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Parkinson disease
- gastric cancer
- cancer
- breast cancer
- non-small cell lung cancer
- HER2 negative hormone receptor negative breast cancer
- oral squamous cell carcinoma
- lung cancer
- breast carcinoma
role in cell
- expression in
- quantity
- apoptosis
- proliferation
- colony formation
- cell death
- binding in
- migration
- number
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- glutaminergic synapse
- exocytic vesicle
- secretory granule lumen
- Cytoplasm
- cell surface
- Plasma Membrane
- vesicles
- endosomal compartment
- alpha granules
- extracellular matrix
- microsomal membrane
- perikaryon
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of smooth muscle cell apoptotic process
- negative regulation of oocyte development
- negative regulation of interleukin-1 beta production
- myoblast differentiation
- positive regulation of Ras protein signal transduction
- positive regulation of mitosis
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of DNA binding
- positive regulation of glycogen biosynthetic process
- wound healing
- skeletal system development
- positive regulation of transcription regulatory region DNA binding
- positive regulation of transcription, DNA-dependent
- positive regulation of calcineurin-NFAT signaling cascade
- positive regulation of cardiac muscle hypertrophy
- positive regulation of protein secretion
- positive regulation of epithelial cell proliferation
- negative regulation of tumor necrosis factor production
- muscle hypertrophy
- bone mineralization involved in bone maturation
- glycolate metabolic process
- insulin-like growth factor receptor signaling pathway
- Ras protein signal transduction
- positive regulation of activated T cell proliferation
- negative regulation of gene expression
- positive regulation of gene expression
- myotube cell development
- myoblast proliferation
- regulation of gene expression
- epithelial to mesenchymal transition
- positive regulation of cell growth involved in cardiac muscle cell development
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- cell proliferation
- positive regulation of glycoprotein biosynthetic process
- positive regulation of cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- positive regulation of glycolysis
- positive regulation of insulin-like growth factor receptor signaling pathway
- positive regulation of smooth muscle cell proliferation
- response to heat
- positive regulation of fibroblast proliferation
- proteoglycan biosynthetic process
- satellite cell maintenance involved in skeletal muscle regeneration
- positive regulation of smooth muscle cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
- activation of protein kinase B activity
- negative regulation of release of cytochrome c from mitochondria
- signal transduction
- positive regulation of glucose import
- positive regulation of MAPK cascade
- muscle organ development
- cell activation
- regulation of protein phosphorylation
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of extrinsic apoptotic signaling pathway
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- insulin-like growth factor binding protein complex
- exocytic vesicle
- platelet alpha granule lumen
- extracellular space
- alphav-beta3 integrin-IGF-1-IGF1R complex
- extracellular region
- insulin-like growth factor ternary complex
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- integrin binding
- insulin receptor binding
- hormone activity
- insulin-like growth factor receptor binding