Bmp2k Gene Summary [Rat]
Predicted to enable AP-2 adaptor complex binding activity; phosphatase regulator activity; and protein serine/threonine kinase activity. Predicted to be involved in positive regulation of Notch signaling pathway; regulation of bone mineralization; and regulation of clathrin-dependent endocytosis. Predicted to be located in nuclear speck. Predicted to be active in cytoplasm and nucleus. Orthologous to human BMP2K (BMP2 inducible kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmp2k |
| Official Name | BMP-2 inducible kinase [Source:RGD Symbol;Acc:1564828] |
| Ensembl ID | ENSRNOG00000002040 |
| Bio databases IDs | |
| Aliases | BMP-2 inducible kinase |
| Synonyms | 4933417M22Rik, BIKE, BMP-2 inducible kinase, HRIHFB2017, LOC289485 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bmp2k often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- phosphatase regulator
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- BMP-2-inducible protein kinase C-terminus
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- productive infection by HIV-1
role in cell
- activation
- stabilization in
- stabilization
- fludarabine resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bmp2k gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Notch signaling pathway
- regulation of clathrin-mediated endocytosis
- regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
Molecular Function
What the gene product does at the molecular level
- ATP binding
- phosphatase regulator activity
- protein binding
- protein serine/threonine kinase activity
- AP-2 adaptor complex binding