KIF2B Gene Summary [Human]
Predicted to enable microtubule binding activity and microtubule motor activity. Involved in metaphase plate congression; microtubule depolymerization; and regulation of chromosome segregation. Located in intercellular bridge; mitotic spindle; and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KIF2B |
| Official Name | kinesin family member 2B [Source:HGNC Symbol;Acc:HGNC:29443] |
| Ensembl ID | ENSG00000141200 |
| Bio databases IDs | |
| Aliases | kinesin family member 2B |
| Synonyms | 1700063D03Rik, kinesin family member 2B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin motor, catalytic domain
- microtubule binding
- Myosin and Kinesin motor domain
- Kinesin motor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- centrosome
- midbody
- cytoplasmic bridges
- cytosol
- nucleoli
- central spindle
- mitotic spindle
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of chromosome segregation
- cell division
- metaphase plate congression
- microtubule-based movement
- microtubule depolymerization
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- microtubule cytoskeleton
- centrosome
- mitotic spindle
- spindle
- cytosol
- kinesin complex
- kinetochore
- nucleolus
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- microtubule binding