CDC34 Gene Summary [Human]
The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDC34 |
| Official Name | cell division cycle 34, ubiqiutin conjugating enzyme [Source:HGNC Symbol;Acc:HGNC:1734] |
| Ensembl ID | ENSG00000099804 |
| Bio databases IDs | |
| Aliases | cell division cycle 34, ubiqiutin conjugating enzyme, ubiquitin conjugating enzyme E2 R1 |
| Synonyms | AI327276, cell division cycle 34, cell division cycle 34, ubiqiutin conjugating enzyme, E2-CDC34, Serine Protease, UBC3, UBCH3, UBE2R1, Ubiquitin conjugating enzyme e2-32 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDC34 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
- C-terminal extension
Pathways
Biological processes and signaling networks where the CDC34 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Antiproliferative Role of TOB in T Cell Signaling
- Cell Cycle: G1/S Checkpoint Regulation
- Cell Cycle: G2/M DNA Damage Checkpoint Regulation
- Cyclins and Cell Cycle Regulation
- Hypoxia Signaling in the Cardiovascular System
- Iron homeostasis signaling pathway
- NRF2-mediated Oxidative Stress Response
- Protein Ubiquitination Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Burkitt lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- renal cell carcinoma
- renal cell cancer
- placenta accreta spectrum
role in cell
- cell death
- accumulation in
- apoptosis
- quantity
- binding in
- formation
- prometaphase
- mobilization
- formation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDC34 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- DNA-dependent DNA replication initiation
- protein K48-linked ubiquitination
- response to growth factor stimulus
- protein polyubiquitination
- positive regulation of inclusion body assembly
- negative regulation of cAMP-mediated signaling
- positive regulation of neuron apoptotic process
- ubiquitin-dependent protein catabolic process
- proteasomal ubiquitin-dependent protein catabolic process
- G1/S transition of mitotic cell cycle
- cellular response to interferon-beta
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ATP binding
- protein binding