SLC14A1 Gene Summary [Human]
The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. [provided by RefSeq, Mar 2009]
Details
| Type | Retained Intron |
| Official Symbol | SLC14A1 |
| Official Name | solute carrier family 14 member 1 (Kidd blood group) [Source:HGNC Symbol;Acc:HGNC:10918] |
| Ensembl ID | ENSG00000141469 |
| Bio databases IDs | |
| Aliases | solute carrier family 14 member 1 (Kidd blood group) |
| Synonyms | 2610507K20Rik, 3021401A05Rik, HsT1341, HUT11, HUT11A, JK, Jk(a), Jk(b), RACH1, RACH2, Riken cDNA 3021401a05, solute carrier family 14 member 1 (Kidd blood group), solute carrier family 14 (urea transporter), member 1, UrT2, UT1, UT3, UT-B, UT-B1, UTE |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC14A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- urea transporter
- protein binding
- water transporter
- transporter
- urea channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- dermatomyositis
- Kidd blood group deletion
- schizophrenia
- polyuria
- bladder carcinoma
- growth failure
- early onset hypertension
- bladder cancer
regulates
- creatinine
- urea
- water
- chloride
- blood urea nitrogen
role in cell
- number
- osmotic water permeability
- morphology
- development
- mean corpuscular volume
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC14A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- urea transport
- water transport
- transmembrane transport
- urea transmembrane transport
- establishment of localization in cell
Cellular Component
Where in the cell the gene product is active
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- urea channel activity
- water transmembrane transporter activity
- urea transmembrane transporter activity