ELAC1 Gene Summary [Human]
Predicted to enable 3'-tRNA processing endoribonuclease activity. Predicted to be involved in tRNA 3'-trailer cleavage, endonucleolytic. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ELAC1 |
| Official Name | elaC ribonuclease Z 1 [Source:HGNC Symbol;Acc:HGNC:14197] |
| Ensembl ID | ENSG00000141642 |
| Bio databases IDs | |
| Aliases | elaC ribonuclease Z 1, tRNA Z (short form), RNaseZ(S) |
| Synonyms | 2610018O07RIK, 8430417G19Rik, D29, elaC ribonuclease Z 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ELAC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta-lactamase superfamily domain
- tRNA-specific ribonuclease
- enzyme
- metallo-hydrolase-like_MBL-fold
- ribonuclease Z
- tRNase Z endonuclease
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ELAC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rescue of stalled ribosome
- tRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- tRNA-specific ribonuclease activity
- 3'-tRNA processing endoribonuclease activity