TBRG1 Gene Summary [Human]
Involved in several processes, including DNA replication; protein localization to nucleoplasm; and protein stabilization. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | TBRG1 |
| Official Name | transforming growth factor beta regulator 1 [Source:HGNC Symbol;Acc:HGNC:29551] |
| Ensembl ID | ENSG00000154144 |
| Bio databases IDs | |
| Aliases | transforming growth factor beta regulator 1, nuclear interactor of ARF and MDM2 |
| Synonyms | mFLJ00213, NIAM, TB-5, Transforming Growth Factor Beta Regulated Gene 1, transforming growth factor beta regulator 1, Transforming Growth Factor β Regulated Gene 1, transforming growth factor β regulator 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TBRG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F/Y rich C-terminus
- protein binding
- F/Y-rich N-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TBRG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication
- negative regulation of cell proliferation
- regulation of cell cycle
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding