KLF11 Gene Summary [Human]
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Details
| Type | Protein Coding |
| Official Symbol | KLF11 |
| Official Name | Kruppel like factor 11 [Source:HGNC Symbol;Acc:HGNC:11811] |
| Ensembl ID | ENSG00000172059 |
| Bio databases IDs | |
| Aliases | Kruppel like factor 11, KLF transcription factor 11 |
| Synonyms | 9830142A17, D12Ertd427e, FKLF, FKLF1, KLF11 (MODY7), KLF transcription factor 11, Kruppel-like transcription factor 11, MODY7, Tcfcp2l2, TIEG2, Tieg2b, TIEG3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLF11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- nucleic acid binding
- Sin3 binding domain
- transcriptional regulatory domain 3
- protein binding
- N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins
- sequence-specific DNA binding
- C2H2-type zinc ribbon
- C2H2-type zinc finger
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- transcription repression domain
- double-stranded DNA binding
- Zinc-finger double domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the KLF11 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- lung adenocarcinoma
- breast cancer
- leiomyoma
- leiomyomatosis
- maturity-onset diabetes of the young type 7
- adenomyosis
- lung adenocarcinoma formation
- uterine leiomyoma
- monogenic diabetes
role in cell
- proliferation
- expression in
- activation in
- apoptosis
- cell death
- production in
- growth
- transactivation in
- oxidative capacity
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- focal adhesions
- cytosol
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLF11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of cell proliferation
- apoptotic process
- positive regulation of apoptotic process
- regulation of G1/S transition of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- focal adhesion
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity